apalutamide will lessen the level or effect of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medicine which might be CYP3A4 substrates may lead to decrease exposure to those drugs.Minor (1)modafinil will raise the level or ef